Not at all, it works for any ratios, that's what you enter on the configuration screen.
But if you have an overall gear ratio from the motor shaft of say 336:1, and the worm gear has a ratio of 144:1, then you get a motor gear ratio of (336:1)/(144:1) = 2.3333333:1.
For example, my mount has a worm gear of 144:1, and I use a 40T gear on the worm screw and a 15T gear on the motor shaft, giving me an overall gear ratio of 40:15 * 144:1 = 384:1. I enter into my config setup, worm ratio = 144:1, and motor ratio = 2.666667:1 (=40:15).